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Epithelial-mesenchymal interactions in the developing lung.
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Epithelial-mesenchymal interactions in the developing lung.

作者: JM Shannon 有關機構: Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. john.shannon@chmcc.org; BA Hyatt
版本/格式: 文章 文章 : 英語
資源:Annual review of physiology, 2004; 66: 625-45
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提要:
Classical experiments in embryology have shown that normal growth, morphogenetic patterning, and cellular differentiation in the developing lung depend on interactive signaling between the endodermal epithelium and mesenchyme derived from splanchnic mesoderm. These interactions are mediated by a myriad of diffusible factors that are precisely regulated in their temporal and spatial expression. In this review we  再讀一些...
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文件類型 文章
所有的作者/貢獻者: JM Shannon 有關機構: Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. john.shannon@chmcc.org; BA Hyatt
ISSN:0066-4278
語言註釋: English
專有的識別號: 112065437
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摘要:

Classical experiments in embryology have shown that normal growth, morphogenetic patterning, and cellular differentiation in the developing lung depend on interactive signaling between the endodermal epithelium and mesenchyme derived from splanchnic mesoderm. These interactions are mediated by a myriad of diffusible factors that are precisely regulated in their temporal and spatial expression. In this review we first describe factors regulating formation of the embryonic foregut. We then discuss the experiments demonstrating the importance of tissue interactions in lung patterning and differentiation. Finally, we detail the roles that a few key signaling systems-fibroblast growth factors and their receptors, sonic hedgehog and Gli genes, Wnt genes and beta-catenin, and BMP4-play as mediators of epithelial-mesenchymal interactions in the developing lung.
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